Mystery has gripped the Hamptons set – after a celebrity ‘on Ozempic’ reportedly lost control of their bowels in a bed in Gwyneth Paltrow‘s home.  

A party at the star’s holiday home took something of an embarrassing turn when an unnamed A-lister ‘using the wonder drug’ was allegedly forced to flee after leaving an unsightly mess in their bed.

Word of the mortifying incident is said to have quickly spread through Long Island’s exclusive enclave, sparking a guessing game over who the mystery guest could be.

Unable to face the consequences of the Ozempic-induced diarrhoea, the star reportedly snuck out of Paltrow’s sprawling home and headed back to New York City to hide in shame.

Speculation has begun over the mystery celebrity who was forced to flee Gwyneth Paltrow’s home in The Hamptons after suffering an awkward side-effect to weight loss drug Ozempic

An unfortunate houseguest, who was rumoured to have stayed at Gwyneth’s home in the New York hotspot (pictured), suffered with a ‘catastrophic’ case of diarrohea

The medication, typically used to treat diabetes, has quickly become known as Hollywood’s ‘worst kept slimming secret’, allowing people to shed weight quickly.

Yet while the benefits of the jab have spread like wildfire in California and beyond, many have failed to relay the the common side-effect that affects one in 10 users.

The active ingredient of semaglutide not only triggers weight loss but causes gastrocolic reflex, which can lead to explosive and uncontrollable diarrhoea. 

The embarrassing ‘scandal’ was first reported in a weekly gossip magazine as a blind item.

It read: ‘Ozempic-induced diarrohea is becoming a very hot topic of conversation between hosts there — because so many of their guests are using it,’ the recent blind item claimed. So expect laundrettes to be fully booked from July 4.’

There are no suggestions that Paltrow herself has ever used or was using Ozempic or similar medication, only that a guest at her house might have experienced the unpleasant side-effects of the drug. 

MailOnline is also not suggesting that a celebrity named or pictured in this story is suffering or has ever suffered from the gastrointestinal side effect described in the Popbitch newsletter.

In recent months, a handful of celebrities have admitted to using the Ozempic, including Oprah Winfrey, Elon Musk, Sharon Osbourne, Chelsea Handler and Robbie Williams.

Amongst them is comedian Amy Schumer, who admitted taking the drug in 2022 but announced in June 2023 she had quit due to side effects. ‘I was one of those people who felt so sick,’ she said. 

Weight loss drugs work by mimicking GLP-1, a hormone made naturally in the body that helps slow the passage of food through the stomach, in turn making people feel less hungry. 

Oprah Winfrey previously admitted that she relief on ‘weight loss medication’ to slim down. There is no suggestion she has experienced side effects (left in 2018 and right in 2024)

Amy Schumer admitted to taking Ozempic in June 2023 but stopped due to the side-effects (pictured in May 2024)

It also alters the brain’s appetite regulation so that users feel satisfied despite eating less and they also don’t experience cravings for treat foods. 

Clinical trials show that 30 per cent of patients experience diarrohea on Wegovy, compared to 16 percent on the placebo, according to the drug’s prescribing information.

Common side effects of Ozempic include constipation, diarrhea, nausea, vomiting, and abdominal pain, according to the drug’s label.

Meanwhile, longer-term side-effects have also started to emerge.

Muscle loss is one key side effect after scientists looking into the GLP-1 drugs showed roughly 40 per cent of weight loss is muscle mass rather than fat.

This can have serious long term health impacts as not only are muscles needed to burn calories but for those who are middle-aged or elderly, muscle loss can lead to fragility or even early death.  

Less common complications of GLP-1 medications are gallstones, increased heart rate, kidney damage and pancreatitis — a condition where the pancreas rapidly becomes painfully inflamed.

Another serious concern is gastroparesis, a severe disorder where the stomach muscles become effectively paralysed and the stomach does not empty, and sufferers vomit days-old food. 

For some patients, the only remedy for gastroparesis may be a gastric bypass.