Elizabeth Holmes must report to prison May 30 to begin serving her 11-year sentence for fraud and conspiracy, a judge ruled, after a court rejected her bid to remain free while she appeals her conviction.

Holmes, 39, is the founder of Theranos, a blood-testing start-up that failed after a public scandal. She rose to prominence as a health-care innovator and self-made business executive, only to fall from grace when the Wall Street Journal revealed in 2015 that her technology did not work as advertised.